Effect of Ganoderma lucidum on radioprotection in Mice

The characteristic constituents of Ganoderma lucidum, such as polysaccharides, triterpenoids, nucleic acids, and small proteins, have been found and proved to have many special pharmacological properties. Mice have been used to extensively investigate the effects of G. lucidum. Experiments with mice investigating the effects of concentrates of G. lucidum have never been reported. The purpose of this investigation was to understand the effect of G. lucidum feeding on blood biochemistry and immunocompetence in mice. Complete blood count (CBC) and blood biochemistry were surveyed routinely. Cellular-mediated immunity was monitored using flow cytometry to survey the percentage changes in CD3 + , CD4 + , and CD8 + T-lymphocytes and B-lymphocytes in the peripheral blood lymphocytes (PBL). The effect of G. lucidum on humoral immunity was examined with a fast plate agglutination test to know the manifestation and change in the titer of specific anti-egg albumin antibodies in the serum after egg albumin injection. The findings on CBC and blood biochemistry indicated that G. lucidum was 9